Autoinactivation of Neuronal AMPA Receptors via Glutamate-Regulated TARP Interaction
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چکیده
منابع مشابه
Autoinactivation of Neuronal AMPA Receptors via Glutamate-Regulated TARP Interaction
Neuronal AMPA receptors autoinactivate at high concentrations of glutamate, i.e., the current declines at glutamate concentrations above 10-100 microM. The mechanisms underlying this phenomenon are unclear. Stargazin-like TARPs are AMPA receptor auxiliary subunits that modulate receptor trafficking and channel properties. Here, we found that neuronal AMPA receptors and recombinant AMPA receptor...
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3 Zhiqiang Chen,1,2 Marcello Peppi,1,2 Sharon G. Kujawa,1,2,3 and William F. Sewell,1,2,4 4 5 6 1Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, 7 Boston, Massachusetts 02114, USA; 8 2Eaton-Peabody Laboratory, Department of Otolaryngology; 9 3Department of Audiology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, 10 Boston, Massachusetts 02114, USA; ...
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ژورنال
عنوان ژورنال: Neuron
سال: 2009
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2008.11.009